American Cruise Lines has multiple ships that offer Mississippi River cruises out of New Orleans - including modern ships and classic paddlewheelers.
The video below provides a full introduction to a round-trip cruise from New Orleans.
American Cruise Lines has multiple ships that offer Mississippi River cruises out of New Orleans - including modern ships and classic paddlewheelers.
The video below provides a full introduction to a round-trip cruise from New Orleans.
The American Serenade is a thoroughly modern new ship from the exterior to the interior. It's spacious and elegant. It features a 4-story glass atrium, fitness room, yoga studio, study, lounges, restaurant, cafe and sun deck. The staterooms have private balconies.
Good news for solo travelers - the American Serenade has some single staterooms. It's the comfortable way to take a cruise by yourself. The ship also offers suites and generously sized regular staterooms.
Mississippi River round-trip cruises offer the convenience of departing and arriving from New Orleans.
7-night Mississippi River cruises. Round-trip cruise from New Orleans to Oak Alley (Louisiana), Baton Rouge (Louisiana), Natchez (Mississippi), Vicksburg (Mississippi) and St Francisville (Louisiana).
• 2025 departures: March 10, March 16, March 22, March 29, April 4, April 10, April 16, April 22, April 28, May 4, May 10, May 16, May 22, May 28, July 1, October 10, October 16, October 22, October 28, November 3, November 9, November 15, November 16.
• 2026 departures: February 16, February 22, February 28, March 6, March 12, March 25, March 28, April 3, April 9, April 15, April 21, April 27, May 3, May 9, May 15, May 21, May 27, June 16, October 9, October 12, October 18, October 24, October 30, November 5, November 11, November 17, November 23, November 29.
Lower Mississippi River cruises are classic one-way voyages from New Orleans to Memphis.
7-night Mississippi River one-way cruises. One-way from New Orleans to Memphis (Tennessee), with stops at Oak Alley (Louisiana), St Francisville (Louisiana), Natchez (Mississippi), Vicksburg (Mississippi) and Cleveland (Mississippi).
• 2025 departures: February 21, February 25, March 7, March 11, March 12, March 21, March 25, March 28, April 4, April 8, April 11, April 18, April 22, April 25, May 2, May 6, May 9, May 16, May 20, May 30, June 4, June 17, July 15, August 26, September 26, October 7, October 16, October 21, October 31, November 4, November 14, November 28, December 12, December 26.
• 2026 departures: February 20, February 24, March 6, March 10, March 20, March 24, March 31, April 3, April 7, April 14, April 17, April 21, April 24, May 1, May 5, May 8, May 15, May 19, May 29, June 2, July 7, July 14, September 1, September 25, October 15, October 30, November 3, November 10, November 13, November 24, November 28, December 8, December 22, December 24.
Mississippi Explorer cruises are longer one-way voyages from New Orleans to Memphis.
11-night Mississippi River one-way cruises. One-way from New Orleans to Memphis (Tennessee), with stops at Oak Alley (Louisiana), Baton Rouge (Louisiana), St Francisville (Louisiana), Natchez (Mississippi), Vicksburg (Mississippi), Cleveland (Mississippi) and Tunica (Mississippi).
• 2025 departures: March 26, April 12, October 30.
• 2026 departures: March 18, April 7, October 29.
Complete Mississippi River Experience is the longest available.
22-night one-way cruise from New Orleans to St Paul (Minnesota), with stops at Oak Alley (Louisiana), Baton Rouge (Louisiana), St Francisville (Louisiana), Natchez (Mississippi), Vicksburg (Mississippi), Greenville (Mississippi), Tunica (Mississippi), Memphis (Tennessee), Cape Girardeu (Missouri), St Louis (Missouri), Hannibal (Missouri), Muscatine (Iowa), Dubuque (Iowa), Winona (Minnesota) and Red Wing (Minnesota).
• 2025 departures: June 13.
• 2026 departures: May 22, June 12.
